methyl 5-methyl-1H-indole-3-carboxylate - Names and Identifiers
methyl 5-methyl-1H-indole-3-carboxylate - Physico-chemical Properties
Molecular Formula | C11H11NO2
|
Molar Mass | 189.21 |
Density | 1.212±0.06 g/cm3(Predicted) |
Boling Point | 345.1±22.0 °C(Predicted) |
Flash Point | 162.5°C |
Vapor Presure | 6.28E-05mmHg at 25°C |
pKa | 15.59±0.30(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.624 |
methyl 5-methyl-1H-indole-3-carboxylate - Introduction
Methyl 5-methylindole-3-carboxylate is an organic compound with the chemical formula C12H11NO2.
Nature:
-Appearance: colorless liquid
-Boiling point: About 245-250 ℃
-Melting point: About 15-18 ℃
-Solubility: Soluble in most organic solvents, such as ethanol, ether and acetone
Use:
- Methyl 5-methylindole-3-carboxylate is widely used in drug synthesis as an important intermediate for the synthesis of indole derivatives.
-It is an important raw material for organic synthesis, which can be used to synthesize drugs, pesticides and other organic compounds.
Method:
- Methyl 5-methylindole-3-carboxylate can be prepared by the following reaction:
1.5-methyl indole and bromoacetate are reacted to generate 5-methyl indole -3-ester.
2.5-Methyl indole-3-ester and methanol are transesterified in the presence of a catalyst to generate Methyl 5-methylindole-3-carboxylate.
Safety Information:
- Methyl 5-methylindole-3-carboxylate is a chemical that is potentially dangerous.
-Avoid contact with skin, eyes and respiratory tract during use.
-Please use in a well-ventilated place and wear appropriate protective equipment, such as gloves and goggles.
-If inhaled or taken by mistake, consult a doctor immediately and show the relevant chemical label or safety data sheet to the doctor.
Last Update:2024-04-09 02:00:44